37^th European Cardiology Conference October 31-01, 2022 London, UK

Nazirova Vafa Balabay is affiliated to the Special Medical Health Complex, Baku, Azerbaijan. Her research interests reflect in her wide range of publications in various national and international journals.

Relevance: Fibrinogen plays a crucial role in the pathophysiological process of cardiovascular diseases. There is sporadic data on the association of FGB gene polymorphism with an increased risk of developing ischemic heart disease in patients with type 2 diabetes mellitus. The DNA region in the regulatory region of the FGB gene, in which guanine (G) is replaced by adenine (A) at position -455, is designated as the G (- 455) A genetic marker. The presence of a substitution affects the intensity of fibrinogen protein synthesis. Fibrinogen is a protein produced in the liver and circulating in the blood plasma. When the blood coagulation system is activated, it undergoes enzymatic cleavage by the enzyme thrombin. The resulting fibrin monomer, under the action of the active blood coagulation factor F13 precipitates in the form of white filaments of fibrin polymer. Fibrin is the basis of a blood clot and subsequently forms a thrombus, completing the clotting process. For this marker, there is no concept of "norm" and "pathology", since the gene polymorphism is being studied. The purpose of the study is to determine the frequency of three genetic variants of the FGB gene in patients with type 2 diabetes mellitus complicated by ischemic heart disease.